The aim of present work is to formulate and evaluate the powder of dried fruit rind of Garcinia indica as Nano-suspension, to improve of poor aqueous solubility. The suitable compositions of Nano-suspension formulation was screened via solubility studies of Garcinia indica in different solvents and tendency of the additives (HPMC & Sodium Alginate) as thickening and suspending agents to prepare oral suspension in various proportions of excipients. These two variables with different concentration were selected, in addition to the Tween 80 as a non-ionic surfactant (less oral irritant) as well the addition of preservative Propylene Glycol, Phosphate Buffer to adjust the formula�s pH in the GIT to prepare the suspension batches. Finally the evaluation of these batches for % Drug release,, Sedimentation volume, viscosity (cp) and Re-dispersibility and for the Nano-suspension was the particle size and particle charge to select the optimize formula and administered as oral suspension of Garcinia indica which is used widely in treatment of varieties of disorders as anti-oxidant, anti-inflammatory and anti-cancer , the selection of a specific action depends on the Pre-clinical and Clinical Trial to exert its action in medicinal field.
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